One
of the advantages of the BBC's new smart phone app is that I can set it
up to provide instant notification of any news stories about 'obesity',
which is now one of the specified topics under the Health section. (I
first wrote to them asking for this in 2007, by the way - the Guardian
has for many years listed all the fat stories under a keyword, allowing
fast location of those of interest). It's immensely useful for someone
interested in staying up to date on news stories around this topic, even
if the quality and tone of the articles themselves often leaves a great
deal to be desired.
http://www.bbc.co.uk/news/health-31794430
According to today's notification, they're once again playing around
with diet pills - medication that induces weight loss through
malabsorption, appetite suppression or metabolic changes without the
restrictive eating associated with conventional dieting or the dangers
of surgery. When anything is regarded as the 'holy grail of modern
medicine', there is inevitably immense pressure on researchers and drug
companies to rush it to market before all the bugs are ironed out. And
in the case of Phen-fen, one of those 'bugs' was that it destroyed
users' heart valves and resulted in elevated rates of often fatal
pulmonary hypertension. Only after numerous deaths and a multi-million
dollar lawsuit did the makers recognise that there was a problem and
pull the drug.
Then there was rimonabant, which was never
approved by the FDA and withdrawn in the EU in 2009 after it became
clear that it was causing major depression and even suicidal ideation in
many users. A year later, sibutramine (widely seen as the great hope
against obesity) was pulled from sale after reports of sudden death,
heart failure and renal failure. Currently the most popular 'diet pill'
is Orlistat, marketed as Redux or Alli, but this is expensive, its
efficacy limited, and its side-effects embarrassing (including fecal
incontinence and excessive flatulence) and potentially dangerous (early
studies have linked its use with liver damage, early signs of colon
cancer and inability to absorb fat-soluble vitamins).
Even
so-called 'natural' supplements aren't without their risks - Ephedra, a
traditional Chinese preparation from the plant of the same name, has in
recent years become popular as a weight-loss supplement but was banned
in the US following mounting evidence of side effects ranging from the
mild (rashes, itchiness, nervousness, irritability) to the deadly (heart
attacks, strokes and seizures resulting in sudden death). Currently the
most popular 'herbal' fat treatment is bladderwrack, a seaweed extract
widely available in pound shops and suchlike in the UK, but despite
being regarded as safe, again its effectiveness has been largely
dismissed.
In other words, there is no safe, effective drug-based
weight loss treatment, and there is unlikely to be, because the
processes which influence weight gain and loss are either complex and
linked to the body's basic biological mechanisms such as appetite,
metabolism, absorption of nutrients, which are difficult to manipulate
without countless unwanted side effects, or like genetics, outside the
realms of that which can be influenced by drug treatments. Of course,
none of this will stop them trying, as it has frequently been said that
the man who invents a way to make fat people safely and permanently thin
(and it would most likely be a man) would become an overnight
billionaire. And there we have it - one of the main motivators behind the 'war on fat people'.